Phenotypes Associated with This Genotype

Genotype
MGI:3720088

• Allelic Composition: Hba^b3(th)/Hba⁺
• Genetic Background: SEC-Hba^b3(th)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:6452 )

• many pups die between birth and weaning

hematopoietic system

abnormal fetal derived definitive erythrocyte morphology ( J:6452 )

• at E13.5 - E15.5, eosinophilic inclusions are seen in liver derived erythrocytes

• however, no abnormalities are seen in yolk-sac derived nucleated erythrocytes

growth/size/body

decreased birth body size ( J:6452 )

• newborn pups are smaller than wild-type littermates

decreased body weight ( J:6452 )

• reduced in heterozygous adults to 18.77 +/- 0.59g compared to 23.79 +/- 0.39g in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:6452