Phenotypes Associated with This Genotype

Genotype
MGI:3720208

• Allelic Composition: Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired righting response ( J:100971 )

limb grasping ( J:100972 )

• when lifted by tail, homozygotes flex the hind limbs, in contrast to wild-type which extend legs

impaired coordination ( J:100971 , J:100972 )

• compared to wild-type mice, mutants are 90 times more likely to fall off of a rotating rod in a rotarod test; (J:100972)

nervous system

abnormal axon morphology ( J:100971 )

• in 3 month old mice, dilated axons are detected in the spinal cord and cerebral cortex, although numbers are fewer than in Tg(Thy1-MAPT)1Vln homozygotes

• cytoskeletons of dilated axons are disrupted, with numerous randomly oriented microtubules engirdling accumulations of pleomorphic vesicles, dense-cored vesicles, and smooth endoplasmic reticulum; ratio of microtubules to neurofilaments in dilated axons is high relative to normal axons

• grouping of atrophic fibers and fascicular atrophy are observed

muscle

muscular atrophy ( J:100971 )

cellular

abnormal cell cytoskeleton morphology ( J:100971 )

• cytoskeletons of dilated axons are disrupted, with numerous randomly oriented microtubules engirdling accumulations of pleomorphic vesicles, dense-cored vesicles, and smooth endoplasmic reticulum; ratio of microtubules to neurofilaments in dilated axons is high relative to normal axons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:100971 , J:100972