Phenotypes Associated with This Genotype

Genotype
MGI:3720677

• Allelic Composition: Tg(DMD-APP*)18Neve/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal microglial cell morphology ( J:100978 )

• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice

immune system

abnormal microglial cell morphology ( J:100978 )

• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice

nervous system

abnormal microglial cell morphology ( J:100978 )

• greatly increased numbers of microglial cells containing phagocytic debris are seen in the hippocampus of 12-month old mice

amyloid beta deposits ( J:100978 )

• hippocampi contain numerous degenerating pyramidal and granule cells

abnormal brain morphology ( J:100978 )

• synaptic degeneration is evident throughout the hippocampi of 12-month old animals

abnormal neuron morphology ( J:100978 )

abnormal hippocampus pyramidal cell morphology ( J:100978 )

• in ~1 year-old mice, numerous large lucent pyramidal neurons containing irregular cytoplasmic accumulations of atypical secondary lysosomes are observed, with comparable severity to ~2-year old Tg(DMD-APP*)7Neve mice

neurodegeneration ( J:100978 )

• mice show comparable degeneration at an earlier age (~1 year) than Tg(DMD-APP*)7Neve mice

hippocampal neuron degeneration ( J:100978 )

homeostasis/metabolism

amyloidosis ( J:100978 )

amyloid beta deposits ( J:100978 )

• hippocampi contain numerous degenerating pyramidal and granule cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:100978