Analysis Tools
immune system
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• dendritic cell number increases with age in the spleen
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• mice exhibit histological changes in the spleen
• loss of follicular architecture is associated with splenomegaly
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• splenomegaly is associated with loss of follicular architecture
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• dendritic cells are spread throughout the periarteriolar lymphoid sheath
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• mice have hyperimmunoglobulinemia
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• elevation in anti-nuclear antibodies occurs as early as 8 weeks in some mice and by 12 to 16 weeks in most mice
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liver/biliary system
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• mice exhibit histological changes in the liver
• polymorphic infiltrate, including Itgax+ dendritic cells and various
• leukocytes, is found around central veins in the liver
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cellular
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• bone marrow dendritic cells are resistant to apoptosis following stimulation with LPS and exposure to CT26 carcinoma cells transfected with human FasL
• splenic dendritic cells are resistant to apoptosis in vivo initiated by cognate OT-1 T cells
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hematopoietic system
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• dendritic cell number increases with age in the spleen
|
|
• mice exhibit histological changes in the spleen
• loss of follicular architecture is associated with splenomegaly
|
|
• splenomegaly is associated with loss of follicular architecture
|
|
• dendritic cells are spread throughout the periarteriolar lymphoid sheath
|
|
• mice have hyperimmunoglobulinemia
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growth/size/body
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• splenomegaly is associated with loss of follicular architecture
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