Phenotypes Associated with This Genotype

Genotype
MGI:3720759

• Allelic Composition: Snca^tm1Rosl/Snca^tm1Rosl
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dopaminergic neuron morphology ( J:60151 )

• when exposed to paired electrical stimuli, striatal brain slices (containing dopamine terminals) from homozygous mice exhibit a faster dopamine release recovery as compared to wild-type

• dopamine discharge and reuptake in response to a single electrical pulse or a train of pulses is comparable to wild-type

behavior/neurological

abnormal locomotor activation ( J:60151 )

• in the absence of amphetamine, locomotor activity in the open field test is comparable to wild-type

• homozygous mice exhibit an attenuated locomotor response after administration of amphetamine as compared to wild-type

homeostasis/metabolism

decreased dopamine level ( J:60151 )

• dopamine content is reduced by 18% in the striatum, however, dopamine content in the ventral midbrain and nucleus accumbens is similar to wild-type

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:60151