Phenotypes Associated with This Genotype

Genotype
MGI:3720803

• Allelic Composition: Tg(Ckm-APPSw)A2Lfa/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:76338 )

• beginning at 10-15 months of age, mice show diminished performance on an accelerating rotarod compared to nontransgenic controls, but this does not reach statistical significance up to 20 months of age

nervous system

amyloid beta deposits ( J:76338 )

• between 10-15 months of age, mice show intracellular amyloid beta (Abeta) deposits in skeletal muscle; increase in mice with Abeta deposits in muscle is seen between 15-20 and 20-30 months of age

muscle

myositis ( J:76338 )

• between 10-15, 15-20, and 20-30 months of age, mice show cellular inflammation in transgenic muscle

• neutrophils are the predominant infiltrating cell type

centrally nucleated skeletal muscle fibers ( J:76338 )

• between 15-20 and 20-30 months of age, muscle fibers with centric nuclei are seen in transgenic mice

immune system

myositis ( J:76338 )

• between 10-15, 15-20, and 20-30 months of age, mice show cellular inflammation in transgenic muscle

• neutrophils are the predominant infiltrating cell type

homeostasis/metabolism

amyloid beta deposits ( J:76338 )

• between 10-15 months of age, mice show intracellular amyloid beta (Abeta) deposits in skeletal muscle; increase in mice with Abeta deposits in muscle is seen between 15-20 and 20-30 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inclusion body myositis		DOID:3429	OMIM:147421	J:76338