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Phenotypes Associated with This Genotype
Genotype
MGI:3720804
Allelic
Composition
Tg(Ckm-APPSw)A6Lfa/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• beginning at 15-20 months of age, mice show significantly diminished performance on the accelerating rotarod relative to nontransgenic controls; diminished ability is observed at 10-15 months of age, but does not reach significance

nervous system
• between 10-15 months of age, mice show intracellular amyloid beta (Abeta) deposits in skeletal muscle; increase in mice with Abeta deposits in muscle is seen between 15-20 and 20-30 months of age

muscle
• between 10-15, 15-20, and 20-30 months of age, mice show cellular inflammation in transgenic muscle
• neutrophils are the predominant infiltrating cell type
• between 15-20 and 20-30 months of age, muscle fibers with centric nuclei are seen in transgenic mice

immune system
• between 10-15, 15-20, and 20-30 months of age, mice show cellular inflammation in transgenic muscle
• neutrophils are the predominant infiltrating cell type

homeostasis/metabolism
• between 10-15 months of age, mice show intracellular amyloid beta (Abeta) deposits in skeletal muscle; increase in mice with Abeta deposits in muscle is seen between 15-20 and 20-30 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
inclusion body myositis DOID:3429 OMIM:147421
J:76338


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory