Phenotypes Associated with This Genotype

Genotype
MGI:3720946

• Allelic Composition: Tg(APP695)3Dbo/0; Tg(PSEN1dE9)S9Dbo/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:123534 )

N

abnormal spatial learning ( J:123534 )

• mice travel shorter distance in open-field and show less activity or excursions into central area; mice remain near periphery of apparatus rather than entering open center of field

abnormal spatial reference memory ( J:123534 )

• 16-18 month-old mice swim farther to find platform and spend less time in platform vicinity than controls

nervous system

amyloid beta deposits ( J:123534 )

• one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus

homeostasis/metabolism

amyloidosis ( J:123534 )

• mice display amyloid beta aggregates at 12 and 20 months

amyloid beta deposits ( J:123534 )

• one month following neuron injection with virus expressing short hairpin RNA to silence Bace1, there is a 38% reduction in amyloid beta burden in hippocampus compared to uninjected hippocampus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:123534
Alzheimer's disease 3		DOID:0110042	OMIM:607822	J:123534