Phenotypes Associated with This Genotype

Genotype
MGI:3721530

• Allelic Composition: Clu^tm1Jakh/Clu^tm1Jakh; Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:78357 , J:107702 )

• by 12 months of age, ~60% of mice show amyloid beta (Abeta) deposition (J:78357)

• decreased percentage of Abeta-immunoreactive deposits that are thioflavine-S-positive (2.46 vs 19.4% thioflavine load/Abeta load) compared to Clu-sufficient mice (J:78357)

• many Abeta deposits have few or no detectable dystrophic neurites around them (J:78357)

• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex (J:107702)

abnormal neurite morphology ( J:78357 )

• a 10-fold reduction in dystrophic neurites in hippocampi at 12 months compared to Clu-sufficient transgenic mice and a 5-fold reduction in number of dystrophic neurites per amyloid deposit

homeostasis/metabolism

amyloidosis ( J:78357 )

• only 20% of mice have thioflavine-S-positive (fibrillar Abeta or amyloid) deposits in the cortex at 12 months

• mice have lower hippocampal amyloid burden (0.89%) at 12 months than Clu-sufficient transgenic mice; amyloid load increases to 2.25% by 15 months

amyloid beta deposits ( J:78357 , J:107702 )

• by 12 months of age, ~60% of mice show amyloid beta (Abeta) deposition (J:78357)

• decreased percentage of Abeta-immunoreactive deposits that are thioflavine-S-positive (2.46 vs 19.4% thioflavine load/Abeta load) compared to Clu-sufficient mice (J:78357)

• many Abeta deposits have few or no detectable dystrophic neurites around them (J:78357)

• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex (J:107702)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:78357