Phenotypes Associated with This Genotype

Genotype
MGI:3721531

• Allelic Composition: Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:78357 , J:107702 )

• by 12 months of age, ~60% of mice show amyloid beta (Abeta) deposition (J:78357)

• mice have a higher percentage of thioflavine-S positive Abeta-immunoreactive deposits than Clu-null mice (J:78357)

• all deposits are surrounded by multiple enlarged, dystrophic neurites (J:78357)

• a 2-fold increase in monomeric Abeta is detected in the brain compared to Clu-deficient transgenic mice (J:78357)

• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex (J:107702)

• mice have prominent deposits that are both diffuse and compact in appearance in hippocampus and in molecular layer of dentate gyrus (J:107702)

abnormal neurite morphology ( J:78357 )

• dystrophic neurites are 10-fold higher compared to Clu-null transgenic mice and more dystrophic neurites (5-fold) are associated with each amyloid deposit

homeostasis/metabolism

amyloidosis ( J:78357 )

• 77% of mice have thioflavine-S-positive (fibrillar Abeta or amyloid) deposits in the cortex

• hippocampal amyloid burden is greater (2.76%) than in Clu-null transgenics at 12 months of age

amyloid beta deposits ( J:78357 , J:107702 )

• by 12 months of age, ~60% of mice show amyloid beta (Abeta) deposition (J:78357)

• mice have a higher percentage of thioflavine-S positive Abeta-immunoreactive deposits than Clu-null mice (J:78357)

• all deposits are surrounded by multiple enlarged, dystrophic neurites (J:78357)

• a 2-fold increase in monomeric Abeta is detected in the brain compared to Clu-deficient transgenic mice (J:78357)

• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex (J:107702)

• mice have prominent deposits that are both diffuse and compact in appearance in hippocampus and in molecular layer of dentate gyrus (J:107702)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:78357