Phenotypes Associated with This Genotype

Genotype
MGI:3721541

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Clu^tm1Jakh/Clu^tm1Jakh; Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:107702 )

• at 6 months of age, most mice have substantial amyloid beta (Abeta) deposits

• by 12 months of age, mice have more amyloid beta (Abeta) deposits in the hippocampus and cortex than other genotypes

• Abeta deposits are more numerous and fill all parts of hippocampus and some of the cortex by 12 months; abundant compact and diffuse plaques are observed

• mice have greater levels of thioflavine-S-positive (fibrillar) Abeta deposits than other genotypes, similar to transgenic homozygotes with normal Apoe and Clu

increased cerebrospinal fluid amyloid beta 40 isoform level ( J:107702 )

• at 3 months, cerebrospinal fluid levels of Abeta₄₀ are elevated; Abeta₄₀ increase is greater than in transgenic, single Apoe-null mice

increased cerebrospinal fluid amyloid beta 42 isoform level ( J:107702 )

• at 3 months, cerebrospinal fluid levels of Abeta₄₂ are elevated

homeostasis/metabolism

amyloidosis ( J:107702 )

• mice have significant amyloid burden, greater than shown by other genotypes

• at 12 months, mice have highest tissue levels of soluble Abeta₄₀ and Abeta₄₂, with high levels of insoluble Abeta₄₂

• at 3 months, mice have higher levels of carbonate soluble Abeta₄₀ and Abeta₄₂ compared to other genotypes

amyloid beta deposits ( J:107702 )

• at 6 months of age, most mice have substantial amyloid beta (Abeta) deposits

• by 12 months of age, mice have more amyloid beta (Abeta) deposits in the hippocampus and cortex than other genotypes

• Abeta deposits are more numerous and fill all parts of hippocampus and some of the cortex by 12 months; abundant compact and diffuse plaques are observed

• mice have greater levels of thioflavine-S-positive (fibrillar) Abeta deposits than other genotypes, similar to transgenic homozygotes with normal Apoe and Clu

increased cerebrospinal fluid amyloid beta 40 isoform level ( J:107702 )

• at 3 months, cerebrospinal fluid levels of Abeta₄₀ are elevated; Abeta₄₀ increase is greater than in transgenic, single Apoe-null mice

increased cerebrospinal fluid amyloid beta 42 isoform level ( J:107702 )

• at 3 months, cerebrospinal fluid levels of Abeta₄₂ are elevated

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:107702