nervous system
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex
• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus
• at 12 months, mice have high levels of insoluble Abeta42
|
• at 3 months, cerebrospinal fluid levels of Abeta40 are elevated
|
• at 3 months, cerebrospinal fluid levels of Abeta42 are elevated
|
homeostasis/metabolism
• by 12 months of age, mice have amyloid beta (Abeta) deposits in the hippocampus and cortex
• deposits are diffuse in appearance; deposition is prominent in dentate hilus, but little or none in molecular layer of dentate gyrus
• at 12 months, mice have high levels of insoluble Abeta42
|
• at 3 months, cerebrospinal fluid levels of Abeta40 are elevated
|
• at 3 months, cerebrospinal fluid levels of Abeta42 are elevated
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Alzheimer's disease | DOID:10652 | J:107702 |