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Phenotypes Associated with This Genotype
Genotype
MGI:3721565
ht4
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 C3H/Rv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:7240 )
• mice do not die following Rickettsia tsutsugamushi infection

immune system
increased macrophage cell number ( J:7240 )
• following Rickettsia tsutsugamushi infection, there is an increase in Ia+ macrophages in peritoneum exudate
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:7240 )
• mice do not die following Rickettsia tsutsugamushi infection

hematopoietic system
increased macrophage cell number ( J:7240 )
• following Rickettsia tsutsugamushi infection, there is an increase in Ia+ macrophages in peritoneum exudate

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory