Analysis Tools
liver/biliary system
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• intrahepatic bile duct morphogenesis is abnormal and results in hepatic cysts
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• at E18.5, the portal tracts are often surrounded by many irregular biliary duct-like structures/cysts
• mice exhibit a ductal plate malformation
• in the liver, the portal vein is surrounded by multiple cysts (likely of biliary cell origin) and irregular duct-like structures
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liver cyst
(
J:124126
)
|
• at E18.5, the portal tracts are often surrounded by many irregular biliary duct-like structures/cysts
• cysts present in the parenchymal tissue appear to form in the absence of a branch of the portal vein
• at 8 weeks, 24 of 26 mice have cysts and four of these mice have more than 50 visible cysts
• cysts are seen in all lobes of the liver, multioculated, almost all filled with a clear fluid, range in size from 0.5mm to 8mm, and worsen with age
• hepatic cysts are a result of abnormal morphogenesis of the intrahepatic bile duct
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endocrine/exocrine glands
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• intrahepatic bile duct morphogenesis is abnormal and results in hepatic cysts
|
growth/size/body
liver cyst
(
J:124126
)
|
• at E18.5, the portal tracts are often surrounded by many irregular biliary duct-like structures/cysts
• cysts present in the parenchymal tissue appear to form in the absence of a branch of the portal vein
• at 8 weeks, 24 of 26 mice have cysts and four of these mice have more than 50 visible cysts
• cysts are seen in all lobes of the liver, multioculated, almost all filled with a clear fluid, range in size from 0.5mm to 8mm, and worsen with age
• hepatic cysts are a result of abnormal morphogenesis of the intrahepatic bile duct
|
