Phenotypes Associated with This Genotype

Genotype
MGI:3721969

cx20

• Allelic Composition: Dync1h1^Cra1/Dync1h1⁺; Tg(SOD1*G93A)1Gur/?
• Genetic Background: involves: C3HeB/FeJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:107901 )

• mice reach end stage by day 167 +/-2.5 SEM (standard error of measurement)

nervous system

astrocytosis ( J:107901 )

• astrocytosis is evident in the cervical and lumbar spinal cord

abnormal spinal cord morphology ( J:107901 )

• degeneration of the motor neurons in the cervical and lumbar spinal cord at end stage with astrocytosis and vacuolization

decreased motor neuron number ( J:107901 )

• degeneration of the motor neurons in the cervical and lumbar spinal cord is visible at end stage

motor neuron degeneration ( J:107901 )

• degeneration of the motor neurons in the cervical and lumbar spinal cord is visible at end stage

behavior/neurological

decreased locomotor activity ( J:107901 )

• motor activity is less than in Tg(SOD1*G93A)1Gur mice but does not deteriorate as quickly

growth/size/body

decreased body weight ( J:107901 )

• weight reduction was not as severe as in Tg(SOD1*G93A)1Gur mice