Phenotypes Associated with This Genotype

Genotype
MGI:3721970

tg38

• Allelic Composition: Tg(SOD1*G93A)1Gur/?
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:107901 )

• mice reach end stage by day 147 +/-2.5 SEM (standard error of measurement)

growth/size/body

decreased body weight ( J:107901 )

• body weights are lower than in wild-type mice and continues to deteriorate after day 115

nervous system

astrocytosis ( J:107901 )

• astrocytosis is evident in the spinal cord

abnormal spinal cord morphology ( J:107901 )

• degeneration of the motor neurons in the cervical and lumbar spinal cord is visible at end stage with astrocytosis and vacuolization

decreased motor neuron number ( J:107901 )

• 50% of motor neurons in the cervical spinal cord and 60% in lumbar spinal cord are degenerated at day 152

behavior/neurological

decreased locomotor activity ( J:107901 )

• mice exhibit decreased locomotor activity compared to wild-type mice after day 115