behavior/neurological
N |
• mice show equal performance to wild-type in the hanging grid test and forced swim test, and show almost no impairment of the righting reflex
|
• double mutants are unable to remain on the rotating rod
|
nervous system
• in 3-month old mice, dilated axons are observed, but numbers are reduced ~10-fold compared to Tg(Thy1-MAPT)2Vln homozygotes in spinal cord and cerebral cortex
• axonal dystrophic changes are dramatically reduced in mice expressing both transgenes
|
muscle
N |
• quadriceps is normal and devoid of any muscle wasting
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Alzheimer's disease | DOID:10652 | J:100971 |