Phenotypes Associated with This Genotype

Genotype
MGI:3723060

• Allelic Composition: P2ry12^tm1Cjf/P2ry12^tm1Cjf
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased platelet aggregation ( J:70017 )

• platelets aggregate poorly in response to ADP and display a reduced sensitivity to thrombin and collagen; platelets retain normal shape change and calcium influx in response to ADP but fail to inhibit adenylyl cyclase

homeostasis/metabolism

decreased platelet aggregation ( J:70017 )

• platelets aggregate poorly in response to ADP and display a reduced sensitivity to thrombin and collagen; platelets retain normal shape change and calcium influx in response to ADP but fail to inhibit adenylyl cyclase

increased bleeding time ( J:70017 )

• mutants display prolonged bleeding times (more than 30 min vs. 3.5 min in wild-type)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
platelet-type bleeding disorder 8		DOID:0060692	OMIM:609821	J:70017