Phenotypes Associated with This Genotype

Genotype
MGI:3723122

• Allelic Composition: Fts/Fts
• Genetic Background: B6.Cg-Fts

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal tail position or orientation ( J:42770 )

• Background Sensitivity: random orientation of the tail

embryo

abnormal developmental patterning ( J:42770 )

incomplete embryo turning ( J:42770 )

• Background Sensitivity: at E9.5

abnormal left-right axis patterning ( J:42770 )

• Background Sensitivity: bilateral expression pattern of Nodal and "Lefty" in lateral plate mesoderm rather than normal left side expression

abnormal notochord morphology ( J:98371 )

• does not undergo normal ventral displacement

cardiovascular system

abnormal direction of heart looping ( J:42770 )

• Background Sensitivity: heart looping can occur in either direction

nervous system

abnormal motor neuron morphology ( J:98371 )

• motor neuron expansion ventrally in the neural tube toward the midline

• some dorsal expansion as well

• V3 neurons greatly reduced