Phenotypes Associated with This Genotype

Genotype
MGI:3723214

• Allelic Composition: Atp2c1^tm1Ges/Atp2c1⁺
• Genetic Background: involves: 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Squamous cell papillomas and carcinomas in Atp2c1^tm1Ges/Atpc1⁺ adults

neoplasm

increased esophageal papilloma incidence ( J:124662 )

• of the 6 mice with squamous cell carcinomas two had an esophageal papilloma at 22 months of age

increased skin papilloma incidence ( J:124662 )

• of the 6 mice with squamous cell carcinomas one had a skin papilloma at 2 years of age

increased squamous cell carcinoma incidence ( J:124662 )

• 6 of 26 mice (over 20 months of age) displayed squamous cell tumors of keratinized epthelial cells compared to 0 wild-type mice at the same age

• 3 of the 6 mice with squamous cell carcinomas had carcinomas of the skin at 20 - 22 months of age

integument

increased skin papilloma incidence ( J:124662 )

• of the 6 mice with squamous cell carcinomas one had a skin papilloma at 2 years of age

digestive/alimentary system

increased esophageal papilloma incidence ( J:124662 )

• of the 6 mice with squamous cell carcinomas two had an esophageal papilloma at 22 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Hailey-Hailey disease	DOID:0050429	OMIM:169600	J:124662