Phenotypes Associated with This Genotype

Genotype
MGI:3723649

• Allelic Composition: Ndn^tm1.1Mus/Ndn⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hypothalamus morphology ( J:66557 )

• the number of hypothalamic oxytocin- and luteinizing hormone-releasing hormone-producing neurons is decreased in paternal-deficient heterozygous mice

• paternal-deficient mice showed no gross morphological abnormalities

• general histological makers revealed no obvious differences in brain structure in paternal-deficient heterozygous mice

behavior/neurological

abnormal spatial learning ( J:66557 )

• spatial learning assessed in the Morris water maze test show improved ability of the mutant to remember accurately the location of the platform in paternal-deficient heterozygous mice

excessive scratching ( J:66557 )

• skin scraping was significantly increased in paternal-deficient mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:66557