Phenotypes Associated with This Genotype

Genotype
MGI:3757580

• Allelic Composition: Tg(Ins2-CD80)3B7Flv/?
• Genetic Background: involves: C57BL/6 * CBA/Ca * NOD/Caj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

insulitis ( J:26618 )

• H2^g7 homozygous transgenic mice show islet disruption with lymphocytic (T and B cell) infiltration, similar to diabetic NOD controls

• N2 mice after a subsequent backcross to NOD show islet disruption with lymphocytic infiltration as early as 4 weeks while non-transgenic H2^g7 homozygous or heterozygous littermates show varying degrees of insulitis by ~6 weeks

immune system

insulitis ( J:26618 )

• H2^g7 homozygous transgenic mice show islet disruption with lymphocytic (T and B cell) infiltration, similar to diabetic NOD controls

• N2 mice after a subsequent backcross to NOD show islet disruption with lymphocytic infiltration as early as 4 weeks while non-transgenic H2^g7 homozygous or heterozygous littermates show varying degrees of insulitis by ~6 weeks

increased susceptibility to autoimmune diabetes ( J:26618 )

• 2/17 transgenic mice from the first cross to NOD develop diabetes between 10 and 14 weeks, compared to no diabetes in (NOD x C57BL/6)F1 non-transgenic controls

• after a further backcross to NOD, diabetes onset is accelerated relative to transgenic mice from the initial cross to NOD with some developing diabetes at 4 weeks; by 12 weeks, 46.2% of transgenic mice homozygous for H2^g7 develop diabetes compared to no non-transgenic H2^g7 homozygous littermates, or NOD controls which only start to exhibit diabetes at 12 weeks

renal/urinary system

increased urine glucose level ( J:26618 )

homeostasis/metabolism

increased circulating glucose level ( J:26618 )

• transgenic mice exhibit blood glucose in excess of 13.9 mmol (250 mg/dl)

increased urine glucose level ( J:26618 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:26618