Phenotypes Associated with This Genotype

Genotype
MGI:3758089

• Allelic Composition: Tg(Camk2a-DISC1)10Asaw/0
• Genetic Background: C57BL/6-Tg(Camk2a-DISC1)10Asaw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain ventricle morphology ( J:124683 )

♂ • at 6 weeks, the lateral ventricles are enlarged in volume

♂ • at 6 weeks, the normal asymmetry between the left and right lateral ventricles is lost or even reversed

♂ • at 6 weeks, occurrences of left side ventricle enlargement are increased

♂ • at 6 weeks, significant changes in the left-right ratio are observed in the hippocampus but not the cortex or basal ganglia

♂ • increase in left ventricle size is correlated with shrinkage of brain structures on the same side

♂ • T2-weighted right value for the thalamus is increased compared to in wild-type mice

abnormal thalamus morphology ( J:124683 )

♂ • T2-weighted right value for the thalamus is increased compared to in wild-type mice

abnormal hippocampus morphology ( J:124683 )

♂ • at 6 weeks, significant changes in the left-right ratio are observed in the hippocampus but not the cortex or basal ganglia

decreased prepulse inhibition ( J:124683 )

♂ • when prepulse is 74 dB, prepulse inhibition is reduced compared to in wild-type mice

behavior/neurological

abnormal behavior ( J:124683 )

♂ • mice take longer to find hidden food pellets

♂ • however, mice do not display anxiety-associated behaviors, and exhibit normal spatial learning and memory in the Morris water maze, working memory in a Y-maze, and social interactions

enhanced behavioral response to addictive substance ( J:194985 )

• mutants exhibit increased sensitivity to metamphetamine, showing a greater augmentation in locomotion compared to wild-type littermates

impaired swimming ( J:124683 )

♂ • mice exhibit immobility when forced to swim

hyperactivity ( J:124683 )

♂ • mice places in an open field for 2 hours exhibit hyperactivity predominantly in the second hour

homeostasis/metabolism

decreased dopamine level ( J:194985 )

• baseline extracellular dopamine is decreased in the ventral striatum

increased physiological sensitivity to xenobiotic ( J:194985 )

• mutants exhibit increased sensitivity to metamphetamine, showing a higher increase in extracellular dopamine in the ventral striatum compared to wild-type littermates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:124683 , J:194985