Analysis Tools
nervous system
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• inhibitory postsynaptic currents (IPSCs) frequency is increased by 50% relative to in wild-type mice
• IPSC in response to GABA puff is increased relative to in wild-type mice
• IPSC strength is increased by about 50% relative to in wild-type mice
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behavior/neurological
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• spatial learning behavior in a Morris water maze is enhanced
• mice exhibit an increase in ability to find hidden platform in a Morris water maze and a decrease in training days
• after training, mice cross to the precise location of the hidden platform almost twice as often as wild-type mice
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• response to a novel caged adult is decreased compared to in wild-type mice
• mice spend less time interacting with other mice compared to wild-type mice
• however, locomotor activity, motor coordination, exploration of novel objects, and anxiety-related behaviors are normal and mice are capable of learning social interaction behaviors following repeated exposure to the same mouse
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:125344 | ||
