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Phenotypes Associated with This Genotype
Genotype
MGI:3759847
cn5
Allelic
Composition		 Itgavtm2Hyn/Itgavtm2.1Hyn
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgavtm2.1Hyn mutation (0 available); any Itgav mutation (53 available)
Itgavtm2Hyn mutation (2 available); any Itgav mutation (53 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage phagocytosis ( J:125508 )
• macrophages exhibit impaired ability to phagocytose and remove apoptotic cells
colitis ( J:125508 )
• mice develop colitis similar to Itgavtm2Hyn/Itgavtm2.1Hyn;Tg(Tek-cre)1Ywa mice with similar histology and proinflammatory cytokine expression but at a lower rate (30% compared to 100% of Itgavtm2Hyn/Itgavtm2.1Hyn;Tg(Tek-cre)1Ywa mice at 40 weeks)
increased autoantibody level ( J:125508 )
• mice contain higher levels of autoantibodies including ones against tropomyosin, phosphotidylserine, double-stranded DNA and anti-nuclear antibodies compared to in Itgavtm2Hyn heterozygote controls

digestive/alimentary system
colitis ( J:125508 )
• mice develop colitis similar to Itgavtm2Hyn/Itgavtm2.1Hyn;Tg(Tek-cre)1Ywa mice with similar histology and proinflammatory cytokine expression but at a lower rate (30% compared to 100% of Itgavtm2Hyn/Itgavtm2.1Hyn;Tg(Tek-cre)1Ywa mice at 40 weeks)

hematopoietic system
impaired macrophage phagocytosis ( J:125508 )
• macrophages exhibit impaired ability to phagocytose and remove apoptotic cells

cellular
impaired macrophage phagocytosis ( J:125508 )
• macrophages exhibit impaired ability to phagocytose and remove apoptotic cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory