Phenotypes Associated with This Genotype

Genotype
MGI:3759991

cx7

• Allelic Composition: Tg(Pgk1-HA)1.1Vbo/?; Tg(Tcra/Tcrb)1Vbo/?
• Genetic Background: involves: 129 * BALB/c * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased double-positive T cell number ( J:125750 )

• the percentage of double-positive T cells is increased compared to mice with just the TCR transgene (71% vs 62%)

decreased CD4-positive, alpha-beta T cell number ( J:125750 )

• the percentage of CD4 T cells in the thymus is decreased compared to mice with just the TCR transgene (20% vs 31%)

increased regulatory T cell number ( J:125750 )

• 5% of CD4 T cells from lymph nodes are CD25-positive and suppress the proliferation of nave CD4 T cells to hemagglutinin antigen in both in vitro and in vivo assays

• 10% of CD4-positive CD8-negative T cells from the thymus express CD25 and suppress the in vitro proliferation of nave CD4 T cells to hemagglutinin antigen

immune system

increased double-positive T cell number ( J:125750 )

• the percentage of double-positive T cells is increased compared to mice with just the TCR transgene (71% vs 62%)

decreased CD4-positive, alpha-beta T cell number ( J:125750 )

• the percentage of CD4 T cells in the thymus is decreased compared to mice with just the TCR transgene (20% vs 31%)

increased regulatory T cell number ( J:125750 )

• 5% of CD4 T cells from lymph nodes are CD25-positive and suppress the proliferation of nave CD4 T cells to hemagglutinin antigen in both in vitro and in vivo assays

• 10% of CD4-positive CD8-negative T cells from the thymus express CD25 and suppress the in vitro proliferation of nave CD4 T cells to hemagglutinin antigen