Phenotypes Associated with This Genotype

Genotype
MGI:3760113

cx6

• Allelic Composition: Tg(Pgk1-HA)1.1Vbo/?; Tg(Tcra/Tcrb)1Vbo/?
• Genetic Background: C.Cg-Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased regulatory T cell number ( J:112603 )

• there is a substantial increase in the frequencies and absolute numbers of CD25-positive CD4 T cells both in the thymus and peripheral lymph nodes compared to mice that express only the TCR transgene

abnormal regulatory T cell physiology ( J:112603 )

• CD25-positive CD4 T cells from the thymus express higher levels of Foxp3 compared to mice that express only the TCR transgene

hematopoietic system

increased regulatory T cell number ( J:112603 )

• there is a substantial increase in the frequencies and absolute numbers of CD25-positive CD4 T cells both in the thymus and peripheral lymph nodes compared to mice that express only the TCR transgene

abnormal regulatory T cell physiology ( J:112603 )

• CD25-positive CD4 T cells from the thymus express higher levels of Foxp3 compared to mice that express only the TCR transgene