Analysis Tools
immune system
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• in mice by 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
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• by 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
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• there is a 2 to 5 fold reduction in the percentage of CD25-postive CD4 T cells in both the thymus and lymph nodes
• transgeneic expression of Il2rb in the thymus rescues number of regulatory T cells
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• increased in size at 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
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• percentage of CD4 and CD8 T cells that express high levels of activation markers is increased
• T cells are hyporesponsive to inflammatory cytokines as measured by in vitro proliferation assays
• expression of activation markers is normalized upon transfer of 1 x 105 CD25-positive CD4 T cells from wild-type mice
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• in mice by 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
|
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• in mice by 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
|
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• in mice by 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
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• adoptively transfered regulatory T cell expand at least 15 to 20 times until they make up 3-5% of the total cells in the lymph nodes and spleen
• regulatory T cells were unable to engraft in wild-type mice
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hematopoietic system
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• in mice by 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
|
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• by 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
|
|
• there is a 2 to 5 fold reduction in the percentage of CD25-postive CD4 T cells in both the thymus and lymph nodes
• transgeneic expression of Il2rb in the thymus rescues number of regulatory T cells
|
|
• increased in size at 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
|
|
• percentage of CD4 and CD8 T cells that express high levels of activation markers is increased
• T cells are hyporesponsive to inflammatory cytokines as measured by in vitro proliferation assays
• expression of activation markers is normalized upon transfer of 1 x 105 CD25-positive CD4 T cells from wild-type mice
|
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• in mice by 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
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growth/size/body
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• in mice by 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
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cellular
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• in mice by 26 days of age
• can be prevented with adoptive transfer at birth of 1 x 105 CD25-positive CD4 T cells from wild-type mice
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