Phenotypes Associated with This Genotype

Genotype
MGI:3760262

hm2

• Allelic Composition: Il2rb^tm1Mak/Il2rb^tm1Mak
• Genetic Background: C.129-Il2rb^tm1Mak

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:113547 )

• Background Sensitivity: mice die between 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

immune system

increased susceptibility to autoimmune hemolytic anemia ( J:113547 )

• cause of death at 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal lymphocyte morphology ( J:113547 )

abnormal T cell clonal deletion ( J:113547 )

• expected deletion occurs of T cells that recognize BALB/c specific superantigens, indicating the autoimmunity associated with this mouse strain is unlikely to be a failure to eliminate self-reactive T cells

decreased CD8-positive, alpha-beta T cell number ( J:113547 )

• number is reduced by a third upon transfer of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal T cell activation ( J:113547 )

• percentage of CD4 and CD8 T cells that express high levels of activation markers is increased

• T cells are hyporesponsive to inflammatory cytokines as measured by in vitro proliferation assays

• expression of activation markers is normalized upon transfer of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

decreased T cell proliferation ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal immune system organ morphology ( J:113547 )

enlarged spleen ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal marginal zone B cell morphology ( J:113547 )

• extension of marginal zones found in the spleen

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal spleen periarteriolar lymphoid sheath morphology ( J:113547 )

• increase in size

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

enlarged lymph nodes ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

increased anti-double stranded DNA antibody level ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

liver inflammation ( J:113547 )

• large atypical lymphocytes are observed in the liver

• no inflammation is observed in mice that receive transfer of 3 x 10⁴ wild-type CD25-positive CD4 T

liver/biliary system

liver inflammation ( J:113547 )

• large atypical lymphocytes are observed in the liver

• no inflammation is observed in mice that receive transfer of 3 x 10⁴ wild-type CD25-positive CD4 T

hematopoietic system

enlarged spleen ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

increased susceptibility to autoimmune hemolytic anemia ( J:113547 )

• cause of death at 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal lymphocyte morphology ( J:113547 )

abnormal T cell clonal deletion ( J:113547 )

• expected deletion occurs of T cells that recognize BALB/c specific superantigens, indicating the autoimmunity associated with this mouse strain is unlikely to be a failure to eliminate self-reactive T cells

decreased CD8-positive, alpha-beta T cell number ( J:113547 )

• number is reduced by a third upon transfer of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal marginal zone B cell morphology ( J:113547 )

• extension of marginal zones found in the spleen

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal spleen periarteriolar lymphoid sheath morphology ( J:113547 )

• increase in size

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

abnormal T cell activation ( J:113547 )

• percentage of CD4 and CD8 T cells that express high levels of activation markers is increased

• T cells are hyporesponsive to inflammatory cytokines as measured by in vitro proliferation assays

• expression of activation markers is normalized upon transfer of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

decreased T cell proliferation ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

growth/size/body

enlarged spleen ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice

cellular

decreased T cell proliferation ( J:113547 )

• by 3 to 5 weeks of age

• can be prevented with adoptive transfer at birth of 3 x 10⁴ CD25-positive CD4 T cells from wild-type mice