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Phenotypes Associated with This Genotype
Genotype
MGI:3760263
hm3
Allelic
Composition		 Il2rbtm1Mak/Il2rbtm1Mak
Genetic
Background		 D2.129-Il2rbtm1Mak
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rbtm1Mak mutation (5 available); any Il2rb mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell clonal deletion ( J:113547 )
• expected deletion occurs of T cells that recognize DBA/2 specific superantigens, indicating the autoimmunity associated with this mouse strain is unlikely to be a failure to eliminate self-reactive T cells

hematopoietic system
abnormal T cell clonal deletion ( J:113547 )
• expected deletion occurs of T cells that recognize DBA/2 specific superantigens, indicating the autoimmunity associated with this mouse strain is unlikely to be a failure to eliminate self-reactive T cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory