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Phenotypes Associated with This Genotype
Genotype
MGI:3760857
cn3
Allelic
Composition		 Ightm1.2Rsky/Ightm1.2Rsky
Tg(CD19-cre/ERT2)1Cgn/?
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1.2Rsky mutation (0 available); any Igh mutation (39 available)
Tg(CD19-cre/ERT2)1Cgn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:125719 )
• upon tamoxifen treatment, B cells switch immunoglobulin expression from IgG1 to IgM
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization upon activation of B cells

hematopoietic system
abnormal class switch recombination ( J:125719 )
• upon tamoxifen treatment, B cells switch immunoglobulin expression from IgG1 to IgM
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization upon activation of B cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory