Phenotypes Associated with This Genotype

Genotype
MGI:3761175

• Allelic Composition: Tg(MMTV-neu/OT-I/OT-II)CBnel/?; Tg(Trp53R172H)8512Jmr/?
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:122846 )

• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors

• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:122846 )

• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors

• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

integument

increased mammary adenocarcinoma incidence ( J:122846 )

• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors

• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:122846