Phenotypes for Fas Sh2d1a MGI:3761613 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fas^lpr/Fas^lpr Sh2d1a^rpl/Sh2d1a^rpl
Genetic Background	MRL/Mp-Fas^lpr Sh2d1a^rpl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fas^lpr mutation (39 available); any Fas mutation (82 available)
Sh2d1a^rpl mutation (0 available); any Sh2d1a mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immune system physiology ( J:126261 )

• the hypergammaglobulinemia and autoantibody production normally associated with MRL mice are mostly absent in this strain

increased anti-nuclear antigen antibody level ( J:126261 )

• levels are slightly elevated compared to wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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