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Phenotypes Associated with This Genotype
Genotype
MGI:3761790
hm1
Allelic
Composition
Oprm1tm2.1Loh/Oprm1tm2.1Loh
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1tm2.1Loh mutation (0 available); any Oprm1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• a naloxone dose-dependent antinociceptive response that was not observed with wild-type
• when the mice was treated chronically with naltresone, tolerance to the drug including morphine was not observed
• effect of morphine antinociception was not different from wild-type control


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory