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Phenotypes Associated with This Genotype
Genotype
MGI:3762186
Allelic
Composition		 Brca1tm1Brn/Brca1+
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Brn mutation (2 available); any Brca1 mutation (114 available)
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53tm1Brn mutation (18 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:126551 )
• mice develop mammary gland with a latency of 332 days

integument
increased mammary gland tumor incidence ( J:126551 )
• mice develop mammary gland with a latency of 332 days

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:126551 )
• mice develop mammary gland with a latency of 332 days

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:126551

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory