Phenotypes for Brca1 Tg(KRT14-cre)8Brn Trp53 MGI:3762187 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Brca1^tm1Brn/Brca1^tm1Brn Trp53^tm1Brn/Trp53⁺ Tg(KRT14-cre)8Brn/0
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Brn mutation (2 available); any Brca1 mutation (114 available)
Tg(KRT14-cre)8Brn mutation (4 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (239 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 407 days

integument

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 407 days

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 407 days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:126551

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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