Phenotypes Associated with This Genotype

Genotype
MGI:3762188

• Allelic Composition: Brca1^tm1Brn/Brca1^tm1Brn; Trp53^tm1Brn/Trp53^tm1Brn; Tg(KRT14-cre)8Brn/0
• Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 213 days

• 80% of mice develop tumors compared to 63% of Trp53^tm1Jjon/Trp53^tm1Jjon Tg(KRT14-cre)8Jjon mice

• mice develop mammary types of carcinoma (91%), biphasic carcinoma that is poorly defined (3%) and biphasic carcinoma that is well defined (6%)

integument

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 213 days

• 80% of mice develop tumors compared to 63% of Trp53^tm1Jjon/Trp53^tm1Jjon Tg(KRT14-cre)8Jjon mice

• mice develop mammary types of carcinoma (91%), biphasic carcinoma that is poorly defined (3%) and biphasic carcinoma that is well defined (6%)

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland with a latency of 213 days

• 80% of mice develop tumors compared to 63% of Trp53^tm1Jjon/Trp53^tm1Jjon Tg(KRT14-cre)8Jjon mice

• mice develop mammary types of carcinoma (91%), biphasic carcinoma that is poorly defined (3%) and biphasic carcinoma that is well defined (6%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:126551