Phenotypes Associated with This Genotype

Genotype
MGI:3763455

• Allelic Composition: Hcrt^tm1Ywa/Hcrt^tm1Ywa
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal posture ( J:57124 )

• sudden sustained changes in posture which end when activity resumes

• 8-27 episodes in a 4 hour period averaging about 66 seconds in length

abnormal locomotor behavior ( J:57124 )

abnormal locomotor activation ( J:57124 , J:85405 )

• side to side rocking motion in about 75% of behavior arrest episodes (J:57124)

• less affected by intruders (J:85405)

abnormal gait ( J:57124 )

• ataxic gait appears 1-3 sec before episodes of behavior arrest in about 27% of cases

increased vertical activity ( J:57124 )

• burrowing and climbing activity frequently precede posture change

behavioral arrest ( J:57124 )

• frequent periods of behavioral arrest at night when mice are most active

• sudden collapse of head and neck and body falls to the cage floor

• episodes more frequent and begin earlier when mice are housed in groups

• often preceded by chasing, tail biting and social grooming

decreased locomotor activity ( J:85405 )

• dark phase activity significantly reduced

narcolepsy ( J:57124 )

• shortened REM sleep latency during light phase

• increased time and duration of REM sleep during dark phase

• decreased time between REM episodes

• increased non REM sleep time

• decreased awake time and shorter duration of awake episodes

cardiovascular system

increased heart rate ( J:85405 )

• ephemeral increase at low doses

• less effect of intruders

abnormal systemic arterial blood pressure ( J:85405 )

• less affected by intruders

• less affected by hexamethonium and prazosin

decreased mean systemic arterial blood pressure ( J:85405 )

• significantly reduced

• bicucullin stimulation ineffective at very low doses and of shorter duration at higher dose

respiratory system

increased pulmonary respiratory rate ( J:85405 )

• respiratory frequency is significantly increased

nervous system

abnormal nervous system electrophysiology ( J:85405 )

• effect of bicucullin on EEG is of short duration even at higher doses

growth/size/body

increased susceptibility to age related obesity ( J:128233 )

• female but not male mice over 100 days in age have significant increases in body weight compared to littermate controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
narcolepsy		DOID:8986	OMIM:161400 OMIM:605841 OMIM:609039 OMIM:612417 OMIM:612851 OMIM:614223 OMIM:614250	J:57124