Phenotypes Associated with This Genotype

Genotype
MGI:3763734

• Allelic Composition: Tg(Tyrp1-TAg)3434Bee/?
• Genetic Background: involves: BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased eye tumor incidence ( J:75629 )

• eye tumors develop at 2 to 3 months of age with pigmented cells observed in the inguinal lymph nodes and, in some mice, the spleen

• in 1-day old mice, tumors are present in the anterior part of the retinal pigmented epithelium and the optic nerve

• in 14-day old mice, tumors are advanced further and the posterior eye cavity is filled with tumor cells

• tumor cells are poorly pigmented or nonpigmented

• however, islet of pigmented cells can be observed in the optic nerve

mortality/aging

decreased tumor-free survival time ( J:75629 )

• mice die at 11.6 weeks of age likely due to proliferation of tumor cells in the brain and near the optic chiasm

neoplasm

increased eye tumor incidence ( J:75629 )

• eye tumors develop at 2 to 3 months of age with pigmented cells observed in the inguinal lymph nodes and, in some mice, the spleen

• in 1-day old mice, tumors are present in the anterior part of the retinal pigmented epithelium and the optic nerve

• in 14-day old mice, tumors are advanced further and the posterior eye cavity is filled with tumor cells

• tumor cells are poorly pigmented or nonpigmented

• however, islet of pigmented cells can be observed in the optic nerve

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinal cancer		DOID:4645		J:75629