Phenotypes Associated with This Genotype

Genotype
MGI:3765154

• Allelic Composition: Kcnn2^fri/Kcnn2^fri
• Genetic Background: involves: C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal short-term object recognition memory ( J:70213 )

tremors ( J:13711 , J:70213 )

• rapid tremors reminiscent of the quaking phenotype (J:13711)

• tremors are Parkinson-like (J:70213)

abnormal motor coordination/balance ( J:70213 )

• 10,20,and 40 mg/kg L-Dopa improved motor performance

• 10 mg/kg Seligiline treatments improved motor performance

• 20 mg/kg Ropinirole treatment increased motor performance

impaired limb coordination ( J:70213 )

• unable to walk on a rotarod bar

• unable to normally traverse an inclined plane

• while suspended unable to coordinate hindpaws to grasp thread held by front paws

abnormal gait ( J:70213 )

• width of foot placement is greater than for control

short stride length ( J:70213 )

• intrastep distance is also shorter

decreased vertical activity ( J:70213 )

• number rearings significantly increased following adminstration of between 10 and 60 mg/kg L-Dopa

nervous system

abnormal brain white matter morphology ( J:13711 )

• histological evidence of degeneration

abnormal spinal cord white matter morphology ( J:13711 )

• histological evidence of degeneration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:70213