About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3765245
cx2
Allelic
Composition		 Cd4tm1Doi/Cd4tm1Litt
Lag3tm1Doi/Lag3+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Doi mutation (0 available); any Cd4 mutation (84 available)
Cd4tm1Litt mutation (3 available); any Cd4 mutation (84 available)
Lag3tm1Doi mutation (2 available); any Lag3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased double-negative T cell number ( J:33272 )
• about 3 fold increase in percentage of double negative alpha-beta T cells that are found in the lymph node
• about 4 fold increase in number of double negative alpha-beta T cells that are found in the spleen
• about 5 fold increase in in percentage of double negative alpha-beta T cells that are found in the thymus
abnormal CD4-positive, alpha-beta T cell physiology ( J:33272 )
• impaired T-cell dependent B cell response to foreign antigen

hematopoietic system
increased double-negative T cell number ( J:33272 )
• about 3 fold increase in percentage of double negative alpha-beta T cells that are found in the lymph node
• about 4 fold increase in number of double negative alpha-beta T cells that are found in the spleen
• about 5 fold increase in in percentage of double negative alpha-beta T cells that are found in the thymus
abnormal CD4-positive, alpha-beta T cell physiology ( J:33272 )
• impaired T-cell dependent B cell response to foreign antigen

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory