Phenotypes Associated with This Genotype

Genotype
MGI:3766125

• Allelic Composition: Timo/Timo⁺
• Genetic Background: either: B6.Cg-Timo or (involves: C57BL/6J * CBA/CaJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:127183 )

• females and males are significantly heavier by 10 and 18 weeks of age, respectively, compared to non-transgenic controls

• females and males are 57 and 31% heavier than age-matched non-transgenic controls by 69 weeks of age

• increase in body weight is not as severe as in homozygous transgenic mice

increased body length ( J:127183 )

• at 24 weeks of age, mean lengths of female and male mice are increased by about 7 and 3%, respectively

adipose tissue

increased total body fat amount ( J:127183 )

• increase in both total amount and percent of body fat

• however, lean mass is similar to non-transgenic controls unlike in homozygous transgenic mice

increased mesenteric fat pad weight ( J:127183 )

• increase in the weight of the mesenteric fat pads

increased percent body fat/body weight ( J:127183 )

• increase in both total amount and percent of body fat

homeostasis/metabolism

increased circulating LDL cholesterol level ( J:127183 )

• elevation in the LDL but not HDL or total, serum cholesterol levels

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:127183