Analysis Tools
respiratory system
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• after 4 weeks, mice show absence of vascular remodeling of the airways in response to Mycoplasma pulmonis infection wherease wild-type show complex growth and reorganization ot the vascular beds
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• abnormalities in epithelial cell differentiation and mucus secretion are intermediate between wild-type and Igh-6 deficient mice after M. pulmonis infection
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immune system
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• proliferation of intestinal epithelial cells (IECs) and MHC class II expression on IECs is comparable to controls
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• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected
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• bacteria are present in liver and kidney of mice after 4 weeks of M. pulmonis infection, but bacteria are absent from wild-type mouse tissue
• airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection
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hematopoietic system
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• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected
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