Analysis Tools
immune system
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• colitis occurs in mice as they age (4 months and over)
• disease resembles the human disease ulcerative colitis
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• T cells in the thymus do not pass the double positive stage
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• very few T cells are found in the thymus or periphery
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• very few CD8 T cells are found in the thymus or periphery
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• numbers are markedly increased
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• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected
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• airway vascular and airway lymphatic vessel remodeling are impaired or absent compared to wild-type mice after M. pulmonis infection
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respiratory system
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• M. pulmonis infected mice show a diminished or intermediate airway remodeling phenotype when compared to wild-type or Igh-6 deficient mice
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hematopoietic system
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• T cells in the thymus do not pass the double positive stage
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• very few T cells are found in the thymus or periphery
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• very few CD8 T cells are found in the thymus or periphery
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• numbers are markedly increased
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• mice do not produce IgG following infection, although M. pulmonis-specific IgM antibodies are detected
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digestive/alimentary system
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• pronounced depletion of goblet cells resulting from inflammation
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• is observed in older mice
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• caused by neutrophil infiltration
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• occurs in rare cases
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• occurs in mice over 4 months of age
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• colitis occurs in mice as they age (4 months and over)
• disease resembles the human disease ulcerative colitis
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endocrine/exocrine glands
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• caused by neutrophil infiltration
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mortality/aging
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• mortality rates increase after six months of age
• few mice survive longer than one year
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cellular
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• pronounced depletion of goblet cells resulting from inflammation
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| inflammatory bowel disease | DOID:0050589 |
OMIM:PS266600 |
J:15221 | |
