Phenotypes for Lta MGI:3768384 MGI Mouse

decreased susceptibility to induced morbidity/mortality ( J:31129 )

• mice survive doses of LPS that are 100 times as much as the dose that would kill a wild-type mouse

increased susceptibility to induced morbidity/mortality ( J:31129 )

• mice cannot control a dose Listeria monocytogenes that is tolerated by wild-type mice and eventually die from listeriosis with high liver and spleen titers and large necrotic lesions with boundaries of heavily infected hepatocytes

decreased T cell number ( J:31129 )

• CD3+ T cells are decreased (25%+/-3% compared to 45%+/-3% in wild-type mice)

• peripheral T cells are decreased 2-fold compared to wild-type

increased leukocyte cell number ( J:31129 )

• leukocyte cell number is increased 4-fold compared to wild-type

increased B cell number ( J:31129 )

• 65%+/-4% B220+ B cells compared to 44%+/-2% in wild-type mice

• peripheral B cells are increased 6-fold compared to wild-type

abnormal spleen morphology ( J:31129 )

• spleen lymphocyte composition and micro-architecture are altered

• the T cell zones are lost and the marginal zone is ill-defined

abnormal spleen marginal zone morphology ( J:31129 )

• the marginal zone is ill-defined

absent Peyer's patches ( J:31129 )

absent lymph nodes ( J:31129 )

abnormal humoral immune response ( J:31129 )

• mice are unable to mount a primary IgG response to sheep red blood cells

decreased IgA level ( J:31129 )

increased susceptibility to parasitic infection ( J:31129 )