Phenotypes for Dnmt1 MGI:3769047 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dnmt1^tm1Okan/Dnmt1^tm2Enl
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1^tm1Okan mutation (1 available); any Dnmt1 mutation (112 available)
Dnmt1^tm2Enl mutation (1 available); any Dnmt1 mutation (112 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

failure of initiation of embryo turning ( J:129049 )

embryonic growth arrest ( J:129049 )

• at E9.5, mice exhibit developmental arrest with no or few somites (up to 7), no embryo turning and open neural tubes

open neural tube ( J:129049 )

failure of somite differentiation ( J:129049 )

nervous system

open neural tube ( J:129049 )

cellular

decreased cell proliferation ( J:129049 )

• at E9.5, the number of proliferating cells reduced to 42% to 45%

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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