Phenotypes Associated with This Genotype

Genotype
MGI:3769898

cx12

• Allelic Composition: Tcra^tm1Mom/Tcra^tm1Mom; Tcrb^tm1Mom/Tcrb^tm1Mom
• Genetic Background: involves: 129 * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes

decreased double-positive T cell number ( J:3206 )

• double positive cells are not present

arrested T cell differentiation ( J:3206 )

• most T cells in the thymus do no progress to the double negative stage

hematopoietic system

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes

decreased double-positive T cell number ( J:3206 )

• double positive cells are not present

arrested T cell differentiation ( J:3206 )

• most T cells in the thymus do no progress to the double negative stage

endocrine/exocrine glands

thymus hypoplasia ( J:3206 )

• about a 95% reduction in number of total thymocytes