Phenotypes Associated with This Genotype

Genotype
MGI:3769900

hm2

• Allelic Composition: Tcrb^tm1Mom/Tcrb^tm1Mom
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

colitis ( J:15221 )

• mild colitis-like disease occurs in mice over one year in age

thymus hypoplasia ( J:3206 )

• 92% reduction in number of total thymocytes

decreased double-positive T cell number ( J:3206 )

• 94% reduction in number of double positive cells

arrested T cell differentiation ( J:3206 )

• most T cells in the thymus do no progress to the double negative stage

decreased CD4-positive, alpha-beta T cell number ( J:3206 )

• very few T cells are found in the thymus or periphery

decreased CD8-positive, alpha-beta T cell number ( J:3206 )

• very few CD8 T cells are found in the thymus or periphery

digestive/alimentary system

colitis ( J:15221 )

• mild colitis-like disease occurs in mice over one year in age

hematopoietic system

thymus hypoplasia ( J:3206 )

• 92% reduction in number of total thymocytes

decreased double-positive T cell number ( J:3206 )

• 94% reduction in number of double positive cells

arrested T cell differentiation ( J:3206 )

• most T cells in the thymus do no progress to the double negative stage

decreased CD4-positive, alpha-beta T cell number ( J:3206 )

• very few T cells are found in the thymus or periphery

decreased CD8-positive, alpha-beta T cell number ( J:3206 )

• very few CD8 T cells are found in the thymus or periphery

endocrine/exocrine glands

thymus hypoplasia ( J:3206 )

• 92% reduction in number of total thymocytes