Phenotypes Associated with This Genotype

Genotype
MGI:3770247

• Allelic Composition: Tcirg1^oc/Tcirg1^oc
• Genetic Background: C57BL/6J-Vps33a^bf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:28464 )

• mice die between 30 and 40 days of age although one mouse survived longer

skeleton

absent teeth ( J:28464 )

abnormal bone ossification ( J:28464 )

• extra bone deposits are present on the chondrocostal junction and in the hindlimb

failure of bone resorption ( J:28464 )

behavior/neurological

circling ( J:28464 )

• circling behavior is apparent at day 10 to 12 and worsens with age

limbs/digits/tail

clubfoot ( J:28464 )

craniofacial

absent teeth ( J:28464 )

growth/size/body

absent teeth ( J:28464 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
clubfoot		DOID:11836	OMIM:119800	J:28464