mortality/aging
• Background Sensitivity: mean age at death is ~300 days
|
neoplasm
• all animals at time of death/sacrifice have extensive tumor burden
|
• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~20% of animals)
|
• Background Sensitivity: animals are prone to skin papillomas (seen in ~25% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma
|
• 100% of animals show multifocal tumors at time of death/sacrifice
• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death
• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium
• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs
|
• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation
|
• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma
|
digestive/alimentary system
• mutants have multiple aberrant crypt foci (ACF) of the colon
|
endocrine/exocrine glands
• mutants have multiple aberrant crypt foci (ACF) of the colon
|
• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~20% of animals)
|
integument
• Background Sensitivity: animals are prone to skin papillomas (seen in ~25% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma
|
respiratory system
• 100% of animals show multifocal tumors at time of death/sacrifice
• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death
• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium
• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs
|
• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation
|
• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma
|
hematopoietic system
• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~20% of animals)
|
immune system
• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~20% of animals)
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
lung cancer | DOID:1324 |
OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 |
J:68981 |